Engineering a selective small-molecule substrate binding site into a deoxyribozyme.
نویسندگان
چکیده
منابع مشابه
Bioinformatics Designing of 10-23 Deoxyribozyme against Coding Region of Beta-galactosidase Gene
Background: Deoxyribozymes (Dzs) can play a role as gene expression inhibitors at mRNA level. Among Dzs, the 10-23 deoxyribozyme has significant potentials for treatment of diseases. Designed Dz includes a catalytic core made of 15 deoxyribonucleotides and two binding arms consisted of 6-12 nucleotides for site specific binding to target RNA and hydrolysis. The enzyme has characteristic feature...
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عنوان ژورنال:
- Angewandte Chemie
دوره 46 39 شماره
صفحات -
تاریخ انتشار 2007